4.8 Article

Pd-Catalyzed Cross-Coupling Reactions of Amides and Aryl Mesylates

Journal

ORGANIC LETTERS
Volume 12, Issue 10, Pages 2350-2353

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol100720x

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Funding

  1. National Institutes of Health (NIH) [GM-58160]
  2. Nippon Chemical
  3. Boehringer Ingelheim
  4. Department of Chemistry and Interdisciplinary Nanoscience Center, University of Aarhus
  5. NSF [CHE 9808061, DBI 9729592]

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A catalyst, based on a biarylphosphine ligand, for the Pd-catalyzed cross-coupling reactions of amides and aryl mesylates is described. This system allows an array of aryl and heteroaryl mesylates to be transformed into the corresponding N-aryl amides in moderate to excellent yields.

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