4.8 Article

Diels-Alder Reactions of Cyclic Isoimidium Salts

Journal

ORGANIC LETTERS
Volume 12, Issue 20, Pages 4524-4527

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol101831b

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Funding

  1. National Science Foundation
  2. Novartis Pharma AG

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Diels-alder reactions of cyclic isoimidium salts are described. The corresponding cycloadducts are obtained with high regio- and stereoselectivity The use of homochiral cyclic isoimidium salts delivers cycloadducts with excellent diastereoselectivity (>99.1) that can be efficiently converted to enantiometrically pure lactones

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