4.8 Article

Synthesis of Mycobacterial Triacylated Phosphatidylinositol Dimannoside Containing an Acyl Lipid Chain at 3-O of Inositol

Journal

ORGANIC LETTERS
Volume 12, Issue 11, Pages 2618-2621

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol1008137

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Funding

  1. National Science Council [NSC 97-2113-M-001-033-MY3, NSC 98-2119-M-001-008-MY2]
  2. Academia Sinica

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A seven-step synthesis of triacylated phosphatidylinositol dimannoside is described from myo-inositol 1,3,5-orthoformate. It proceeded in 31% overall yield via a highly regioselective and stereoselective 2,6-di-O-D-mannosylation as the key step.

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