4.8 Article

Stereoselective Synthesis of Trisubstituted Aziridines with N-α-Diazoacyl Camphorsultam

Journal

ORGANIC LETTERS
Volume 12, Issue 8, Pages 1668-1671

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol100104v

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Funding

  1. MEXT, Japan

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A Bronsted acid-catalyzed reaction of alpha-substituted alpha-diazocarbonyl compounds bearing camphorsultam as a chiral auxiliary and N-alkoxycarbonyl imines was implemented as an unprecedented means to provide trisubstituted aziridines in a highly stereodefined manner.

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