Journal
ORGANIC LETTERS
Volume 12, Issue 4, Pages 828-831Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol902895e
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- National Institutes of Health [GM-50151]
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Esterification of the trienoic acid with o-xylylene dibromide gave the bis ester that underwent a templated Diels-Alder reaction to afford the macrodiolide stereospecifically in a single step. The synthesis of bistellettadine A was completed in four steps by hydrolysis and side chain elaboration.
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