4.8 Article

Catalytic Asymmetric Total Synthesis of Tangutorine

Journal

ORGANIC LETTERS
Volume 12, Issue 4, Pages 872-875

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol902929a

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Funding

  1. Ministry of Education, Culture, Sports, Science, and Technology, Japan
  2. JSPS

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The first enantioselective total synthesis of tangutorine has been achieved, wherein a Pd-catalyzed asymmetric allylic amination using a chiral diaminophosphine oxide (DIAPHOX) preligand was the key step.

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