Journal
ORGANIC LETTERS
Volume 12, Issue 16, Pages 3634-3637Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol101414b
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Funding
- Ministry of Science and Technology [2009ZX09501-00]
- Chinese Academy of Sciences
- National Natural Science Foundation of China [20632050, 20921091]
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The O-TMS-protected diphenylprolinol-catalyzed cascade double Michael addition reactions of alpha,beta-unsaturated aldehydes with a beta-keto ester bearing a highly electron-deficient olefin unit occur smoothly to afford polysubstituted cyclopentanones. This process allows formation of four contiguous stereocenters in the cyclopentanone ring in one-step with excellent enantioselectivity.
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