4.8 Article

Copper-Catalyzed Cyanation of Heterocycle Carbon-Hydrogen Bonds

Journal

ORGANIC LETTERS
Volume 12, Issue 11, Pages 2517-2519

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol100772u

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Funding

  1. Welch Foundation [E-1571]
  2. NIGMS [R01GM077635]
  3. A. P. Sloan Foundation
  4. Norman Hackerman Advanced Research Program
  5. Camille and Henry Dreyfus Foundation

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A method for regioselective cyanation of heterocycles has been developed. A number of aromatic heterocycles as well as azulene can be cyanated in reasonable to good yields by using a copper cyanide catalyst and an iodine oxidant.

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