Journal
ORGANIC LETTERS
Volume 12, Issue 11, Pages 2492-2495Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol1006373
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Funding
- National Institutes of Health [GM 25439]
- Robert A. Welch Foundation
- Pfizer, Inc.
- Merck Research Laboratories
- Boehringer Ingelheim Pharmaceuticals
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The synthesis of a functionalized, tetracyclic core of N-methylwelwitindolinone C isothiocyanate is reported. The approach features a convergent coupling between an indole iminium ion and a highly functionalized vinylogous silyl ketene acetal followed by an intramolecular palladium-catalyzed cyclization that proceeds via an enolate arylation.
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