Journal
ORGANIC LETTERS
Volume 12, Issue 24, Pages 5740-5743Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol1025348
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- University of Bath
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1,5-Diazabicyclo[4.3.0]non-5-ene (DBN) has been shown to be an effective catalyst for the regioselective Friedel-Crafts C-acylation of pyrroles and indoles in high yields. A detailed mechanistic study implies that DBN is acting as a nucleophilic organocatalyst, with the X-ray crystal structure of a key N-acyl-amidine intermediate having been determined for the first time.
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