4.8 Article

Substituted Pyrroles via Olefin Cross-Metathesis

Journal

ORGANIC LETTERS
Volume 12, Issue 18, Pages 4094-4097

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol101681r

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Funding

  1. EPSRC
  2. Engineering and Physical Sciences Research Council [EP/F029772/1] Funding Source: researchfish
  3. EPSRC [EP/F029772/1] Funding Source: UKRI

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Olefin cross-metathesis (CM) provides a short and convenient entry to diverse trans-gamma-aminoenones. When exposed to either acid or Heck arylation conditions, these intermediates are converted to mono-, di-, or trisubstituted pyrroles. The value of this chemistry is demonstrated by its application to the tetrasubstituted pyrrole subunit of Atorvastatin.

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