4.8 Article

Access to 2,5-Diamidopyrroles and 2,5-Diamidofurans by Au(I)-Catalyzed Double Hydroamination or Hydration of 1,3-Diynes

Journal

ORGANIC LETTERS
Volume 12, Issue 12, Pages 2758-2761

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol1008685

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Funding

  1. Danish National Research Foundation
  2. H. Lundbeck A/S
  3. OChem graduate school
  4. Aarhus University

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A Au(I)-catalyzed hydroamination or hydration of 1,3-diynes to access 2,5-diamidopyrroles and 2,5-diamidofurans has been developed. This method can also be expanded to 2,5-disubstituted furans and 1,2,5-trisubstituted pyrroles including the formation of deuterated heterocycles and O-18-labeled furans.

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