Journal
ORGANIC LETTERS
Volume 12, Issue 21, Pages 4924-4927Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol1020898
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- Alcobendas AT Group (Lilly S.A.)
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A highly regioselective Pd-catalyzed arylation of N-methylpyrazoles with aryl bromides is described. This transformation was studied extensively via automated reaction screening. A Design of Experiments (DoE) approach for optimizing the critical parameters was applied, resulting in excellent conditions for preparing selectively 5-arylpyrazoles in moderate to excellent yields under mild conditions.
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