Journal
ORGANIC LETTERS
Volume 12, Issue 22, Pages 5290-5293Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol102351z
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Funding
- NIH [1SC1GM086271-01A1]
- UPR-RISE
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Monamphilectine A (1), a new diterpenoid beta-lactam alkaloid showing potent antimalarial activity, was isolated in milligram quantities following bioassay-directed extraction of a Puerto Rican marine sponge Hymeniacidon sp. Its structure, established by interpretation of spectral data, was confirmed unequivocally by chemical interconversion and comparison of physical, chemical, and bioactivity data with the natural product. The one-step semisynthesis of monamphilectine A was based on a multicomponent Ugi reaction that also established its absolute stereostructure.
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