Journal
ORGANIC LETTERS
Volume 12, Issue 12, Pages 2754-2757Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol100844v
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Funding
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- Merck Frosst Centre for Therapeutic Research
- University of Toronto
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The methylenindene scaffold can be prepared from readily available gem-dibromoolefins using an efficient palladium-catalyzed tandem intermolecular Suzuki/intramolecular Heck reaction. The reaction is highly modular and proceeds under mild conditions. The choice of ligand was found to be crucial to control the selectivity of the reaction. Isolation of intermediates under different conditions provides insight into the mechanism.
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