4.8 Article

NHC-Iron-Catalyzed Aerobic Oxidative Aromatic Esterification of Aldehydes using Boronic Acids

Journal

ORGANIC LETTERS
Volume 12, Issue 12, Pages 2686-2689

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol100302e

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Funding

  1. Fundacao para a Ciencia e Tecnologia
  2. FEDER [PTDC/QUI-QUI/099389/2008, SFRH/BPD/46589/2008, SFRH/BPD/48219/2008, SFRH/BPD/65455/2009, REDE/1518/REM/2005]
  3. Fundação para a Ciência e a Tecnologia [SFRH/BPD/65455/2009, SFRH/BPD/48219/2008, SFRH/BPD/46589/2008] Funding Source: FCT

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NHC Iron complexes prepared in situ very efficiently afforded benzoates via the aerobic oxidative aromatic esterification of aldehydes with boronic acids. This method uses equimolar amounts of both the aldehyde and the boronic acid allowing the preparation of benzoates in yields up to 97%.

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