4.8 Article

Total Synthesis of Cyanolide A and Confirmation of Its Absolute Configuration

Journal

ORGANIC LETTERS
Volume 12, Issue 12, Pages 2880-2883

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol101022z

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Funding

  1. Duke University
  2. NCBC [2008-IDG-1010]

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The tandem allylic oxidation/oxa-Michael reaction promoted by the gem-disubstituent effect and the 2-methyl-6-nitrobenzoic anhydride (MNBA)-mediated dimerization were explored for the efficient and facile synthesis of cyanolide A.

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