4.8 Article

Benzotetramisole-Catalyzed Dynamic Kinetic Resolution of Azlactones

Journal

ORGANIC LETTERS
Volume 12, Issue 4, Pages 892-895

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol902969j

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Funding

  1. Washington University
  2. NIH Research Resource [P41RR0954]

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Enantioselective acyl transfer catalyst benzotetramisole (BTM) has been found to promote dynamic kinetic resolution of azlactones providing di(1-naphthyl)methyl esters of alpha-amino acids with up to 96% ee.

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