Journal
ORGANIC LETTERS
Volume 12, Issue 17, Pages 3844-3847Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol101527j
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- Italian MIUR (Ministero dell'Istruzione, dell'Universit e della Ricerca)
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A practical and efficient synthesis of 3-substituted hexahydropyrrolo[2,3-b]indole is described. The addition/cyclization of 3-substituted indoles with alpha,beta-dehydroamino esters in the presence of a Lewis acid provides hexahydropyrrolo[2,3-b]indole adducts in good yields and stereoselectivities. This approach has been applied to the concise synthesis of esermethole employing an appropriately substituted indole and an N-acyl dehydroamino ester.
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