4.8 Article

Platinum-Catalyzed Intramolecular Hydroarylation of Allenyl Arenes: Efficient Synthesis of 1,4-Dihydronaphthalenes

Journal

ORGANIC LETTERS
Volume 12, Issue 11, Pages 2570-2573

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol1007857

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Funding

  1. Korea government (MEST) [2009-0087013]
  2. Brain Korea 21 Program
  3. National Research Foundation of Korea [핵09A3015, 2006-0052329] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

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An efficient synthetic method of 1,4-dihydronaphthalenes having various alkyl groups on the 4-position and/or ethoxycarbonyl group on the 2-position through selective intramolecular Pt-catalyzed 6-endo cyclohydroarylation of ethyl 2-benzy1-2,3-alkadienoates was developed. The present method could be further extended to two-fold Pt-catalyzed 6-endo and 7-endo cyclizations.

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