Journal
ORGANIC LETTERS
Volume 12, Issue 10, Pages 2210-2213Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol100424y
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- Swedish Research Council
- Chemical biology platform at the University of Gothenburg
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A novel combination of SmI2, KHMDS, and TsCN can be utilized to introduce a cyano group into structurally diverse and highly sensitive 2-alkyl-chroman-4-ones. Subsequent oxidation allows the formed 2-alkyl-3-cyanochromones to be isolated in yields ranging from 49 to 77%. In addition, alpha-bromoketones and esters were found to undergo equally effective alpha-cyanation.
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