4.8 Article

Stereocontrolled Synthesis of Spirooxindoles through Lewis Acid-Promoted [5+2]-Annulation of Chiral Silyl Alcohols

Journal

ORGANIC LETTERS
Volume 11, Issue 15, Pages 3366-3369

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol901202t

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Funding

  1. NIGMS CMLD [GM-067041]

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The enantioselective synthesis of stereochemically and structurally diverse spirocyclic oxindoles by [5 + 2]-annulation of chiral crotylsilanes bearing a primary alcohol is described. The annulation products were further elaborated to polycyclic oxindoles by Pd(0) catalysis.

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