4.8 Article

Stable Preformed Chiral Palladium Catalysts for the One-Pot Asymmetric Reductive Amination of Ketones

Journal

ORGANIC LETTERS
Volume 11, Issue 2, Pages 265-268

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol802336m

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Funding

  1. CONACyT [166350]
  2. DGAPA [IN209206]

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The application of air stable preformed [(R)-BINAP]PdBr2, [(S)-BINAP]PdBr2, [(R)-Tol-BINAP]PdBr2, and [(S,S)-CHIRAPHOS]PdBr2 complexes in the one-pot asymmetric reductive amination of various carbonyl compounds, leading to chiral amines in very good yields with high enantioselectivities (<99% ee), is reported.

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