4.8 Article

First Total Synthesis of Hinckdentine A

Journal

ORGANIC LETTERS
Volume 11, Issue 1, Pages 197-199

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol802394n

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We have accomplished the first total synthesis of (+/-)-hinckdentine A (1). The key steps are m-CPBA oxidation of 2-arylindole followed by acid-mediated Mannich-type C-C bond formation of 2-hydroxyindolin-3-one, seven-membered ring closure, and regioselective tribromination.

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