Journal
ORGANIC LETTERS
Volume 11, Issue 15, Pages 3458-3461Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol901383j
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- University of California
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An efficient method to access the fused indoline ring system present in a multitude of bioactive molecules has been developed. The strategy involves the condensation of hydrazines with latent aldehydes to ultimately deliver indoline-containing products by way of an interrupted Fischer indolization sequence. Our studies show that the approach will likely be amenable to the synthesis of complex targets, such as the communesin natural products.
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