4.8 Article

One- and Two-Photon Turn-on Fluorescent Probe for Cysteine and Homocysteine with Large Emission Shift

Journal

ORGANIC LETTERS
Volume 11, Issue 6, Pages 1257-1260

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol802979n

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Funding

  1. SERC [052 117 00029]

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A novel dendritic chromophore with efficient intramolecular charge transfer (ICT) and strong two-photon absorption (TPA) was designed as a turn-on fluorescent probe for cysteine (Cys) and homocysteine (Hcy). The probe exhibited greatly enhanced fluorescence intensity as well as a very large emission peak shift (165 nm) upon addition of Cys/Hcy due to ICT switch off. The sensing process was also monitored by two-photon excited fluorescence (TPEF).

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