4.8 Article

Simple Conversion of Enamines to 2H-Azirines and Their Rearrangements under Thermal Conditions

Journal

ORGANIC LETTERS
Volume 11, Issue 12, Pages 2643-2646

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol9006663

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Funding

  1. National Natural Science Foudation of China [20802048]
  2. Cultivation Foundation (13) for New Faculty of Tianjin University [5110109]

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A variety of substituted enamine derivatives were first found to be conveniently converted to the corresponding 2H-azirines mediated by phenyliodine (III) diacetate (PIDA). The formed 2-aryl-2H-azirines could be applied in the synthesis of indole-3-carbonitriles or isoxazoles via thermal rearrangements.

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