Journal
ORGANIC LETTERS
Volume 11, Issue 5, Pages 1087-1090Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol802890b
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Funding
- NIH Intramural Research Program (NIDDK)
- Intramural AIDS Targeted Antiviral Program, Office of the Director, NIH
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Seven new antibacterials, motualevic acids A-F (1-6) and (4E)-(R)-antazirine (7), have been isolated from the marine sponge Siliquariaspongia sp. and their structures elucidated by spectroscopic methods. Motualevic acids A-D are the first glycyl conjugates of the omega-brominated lipid (E)-14,14-dibromotetradeca-2,13-dienoic acid, and motualevic acid F Is the first long-chain 2H-azirine 2-carboxylic acid to be found in nature. Carboxylic acid-containing compounds 1 and 6 inhibit the growth of Staphylococcus aureus and methicillin-resistant S. aureus at 1.2-10.9 mu g/mL.
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