4.8 Article

Synthesis of Carbamates from Diethoxycarbonyl Hydrazine Derivatives by E1cB Eliminative Cleavage of the N-N′-Bond Rather than Reduction

Journal

ORGANIC LETTERS
Volume 11, Issue 24, Pages 5646-5648

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol902313v

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Funding

  1. The Welch Chair [F-0018]
  2. MDS Research Foundation, Inc.

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Treatment of diethoxycarbonyl hydrazine derivatives with methyl bromoacetate/Cs2CO3/MeCN at 50 degrees C followed by heating to 80 degrees C resulted in N-N' bond cleavage to the corresponding carbamates.

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