4.8 Article

Aryl Hydrazide beyond as Surrogate of Aryl Hydrazine in the Fischer Indolization: The Synthesis of N-Cbz-indoles, N-Cbz-carbazoles, and N,N′-Bis-Cbz-pyrrolo[2,3-f]indoles

Journal

ORGANIC LETTERS
Volume 11, Issue 23, Pages 5454-5456

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol902250x

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Funding

  1. Korea Science and Engineering Foundation through Center for Bioactive Molecular Hybrids (CBMH), Yonsei University
  2. BK21 Fellowship

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Aryl hydrazides underwent the Fischer indolization reactions, while the N-carbamate group(s) remained intact to directly provide N-Cbz-indoles. This new method allowed the synthesis of various N-Cbz-carbazoles and N,N'-bis-Cbz-pyrrolo[2,3-f]indoles.

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