Journal
ORGANIC LETTERS
Volume 11, Issue 7, Pages 1579-1582Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol9002288
Keywords
-
Categories
Funding
- National Institute on Drug Abuse [DA11528]
- University of New Orleans
Ask authors/readers for more resources
Both the R and S enantiomers of the amphibian alkaloid noranabasamine were prepared in >30% overall yield with 80% ee and 86% ee, respectively. An enantioselective iridium-catalyzed N-heterocyclization reaction with either (R)- or (S)-1-phenylethylamine and 1-(5-methoxypyridin-3-yl)-1,5-pentanediol was employed to generate the 2-(pyridin-3-yl)-piperidine ring system in 69-72% yield.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available