4.8 Article

Azide Conjugatable and pH Responsive Near-Infrared Fluorescent Imaging Probes

Journal

ORGANIC LETTERS
Volume 11, Issue 23, Pages 5386-5389

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol902140v

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Funding

  1. Science Foundation Ireland

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The synthesis and photophysical characteristics of a pH responsive near-infrared fluorescence imaging probe is described. A key feature is the ability to conjugate the probe by an alkyne-azide cycloaddition reaction and its reversible response of fluorescence intensity across the physiological pH range.

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