4.8 Article

Colorimetric Detection of Thiols Using a Chromene Molecule

Journal

ORGANIC LETTERS
Volume 11, Issue 21, Pages 4918-4921

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol901951h

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Funding

  1. National Natural Science Foundation of China [20801032]
  2. Shanxi Province Science Foundation for Youths [20090210062]
  3. Shanxi Province Foundation for Returness [200815]

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A new thiol-containing colorimetric probe has been developed by using a chromene derivative, 7-nitro-2,3-dihydro-1H-cyclopenta[b]chromen-1-one (1). The molecule exhibited high selectivity and sensitivity for detecting thiol species as cysteine, homocysteine, and glutathione in aqueous solution through a rapid visual color change from colorless to yellow.

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