4.8 Article

Oxidative Carbon-Carbon Bond Formation in the Synthesis of Bioactive Spiro β-Lactams

Journal

ORGANIC LETTERS
Volume 11, Issue 13, Pages 2820-2823

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol901005x

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Funding

  1. Chinese Ministry of Education [706052]
  2. Yunnan Provincial Science & Technology Department [2007B0006Z]
  3. National Natural Science Foudation of China [20832005]

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New oxidative dearomatization procedures leading to Spiro beta-lactams and oxindoles were developed. By a variation of the oxidative reaction conditions, the usefulness of phenolic amides, derived from 4-aminophenol, in the synthesis of structurally different types of molecules was demonstrated.

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