4.8 Article

Silver-Catalyzed Protodecarboxylation of Heteroaromatic Carboxylic Acids

Journal

ORGANIC LETTERS
Volume 11, Issue 24, Pages 5710-5713

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol902482p

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Funding

  1. Engineering and Physical Sciences Research Council
  2. Royal Society
  3. QMUL
  4. EPSRC [EP/G031649/1] Funding Source: UKRI
  5. Engineering and Physical Sciences Research Council [EP/G031649/1] Funding Source: researchfish

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A simple and highly efficient protodecarboxylation procedure for a variety of heteroaromatic carboxylic acids catalyzed by Ag2CO3 and AcOH in DMSO is described. This methodology can also perform the selective monoprotodecarboxylation of several aromatic dicarboxylic acids.

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