4.8 Article

Homologation of Boronic Esters with Lithiated Epoxides for the Stereocontrolled Synthesis of 1,2- and 1,3-Diols and 1,2,4-Triols

Journal

ORGANIC LETTERS
Volume 11, Issue 1, Pages 165-168

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol802651b

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Funding

  1. Deutscher Akademischer Austausch Dienst (DAAD)
  2. Royal Society for a Wolfson Research
  3. EPSRC
  4. Merck

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Lithiated epoxides react stereospecifically with boronic esters to give syn-1,2-diols, a process that can be used iteratively to create triols containing four stereogenic centers.

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