Journal
ORGANIC LETTERS
Volume 11, Issue 22, Pages 5170-5173Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol902051v
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Funding
- Chinese National Programs for Fundamental Research and Development [2006CB-504700]
- Chinese National Programs for High Technology Research and Development [2007AA02Z104]
- NIH [GM086281]
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Tanshinones are abietane-type norditerpenoid quinone natural products that are the bioactive components of the Chinese medicinal herb Salvia miltiorrhiza Bunge. The initial results from a functional genomics-based investigation of tanshinone biosynthesis, specifically the functional identification of the relevant diterpene synthases from S. miltiorrhiza, are reported, The cyclohexa-1,4-diene arrangement of the distal ring poises the resulting miltiradiene for the ensuing aromatization and hydroxylation to ferruginol suggested for tanshinone biosynthesis.
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