Journal
ORGANIC LETTERS
Volume 11, Issue 20, Pages 4716-4719Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol9017529
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Funding
- Chinese Ministry of Education [209054]
- Nanjing University
- Zhejiang Province [Yk2008093]
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A chelation-assisted palladium-catalyzed ortho-cyanation of the sp(2) C-H bond by CuCN provided aromatic nitrites in moderate to good yields. Notably, the reaction could be conducted on a 10 mmol scale. The key intermediate of the natural product of Menispermum dauricum DC was concisely synthesized by the procedure. This new approach represents an exceedingly practical method for the synthesis of aromatic nitriles and offers an attractive alternative to the traditional Sandmeyer reaction.
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