4.8 Article

Organocatalytic Enantioselective Synthesis of Nitrogen-Substituted Dihydropyran-2-ones, a Key Synthetic Intermediate of 1β-Methylcarbapenems

Journal

ORGANIC LETTERS
Volume 11, Issue 17, Pages 3934-3937

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol901544q

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Funding

  1. JSPS/MEXT
  2. Suzuken Memorial Foundation

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Organocatalytic enantioselective cycloadditions providing nitrogen-substituted dihydropyran-2-ones were developed in two catalytic systems. The (3R,4R)-product was a versatile intermediate in the synthesis of 1 beta-methylcarbapenem antibiotics.

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