4.8 Article

Instantaneous Deprotection of Tosylamides and Esters with SmI2/Amine/Water

Journal

ORGANIC LETTERS
Volume 11, Issue 3, Pages 503-506

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol802243d

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Funding

  1. Swedish Natural Science Council

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Sml(2)amine/water mediates instantaneous cleavage of tosyl amides and tosyl esters. Highly hindered, sensitive and functionalized substrates were successfully deprotected in near quantitative yield.

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