4.8 Article

Probing the Lactose•GM3 Carbohydrate-Carbohydrate Interaction with Glycodendrimers

Journal

ORGANIC LETTERS
Volume 11, Issue 3, Pages 559-562

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol802613r

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Funding

  1. NSF
  2. Mizutani Foundation for Glycoscience

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Multivalent glycoconjugates were prepared using generation-4 PAMAM dendrimers, and their interaction with Langmuir monolayers containing GM3 was investigated. Excessive carbohydrate valency adversely affects the carbohydrate-carbohydrate interaction. The GM3 monolayer selectively interacts with lactose-functionalized dendrimers in the presence of calcium ions.

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