Journal
ORGANIC LETTERS
Volume 11, Issue 21, Pages 5014-5017Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol901996g
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- Bundesministerium fur Bildung und Forschung (BMBF) [03F0415A]
- University of Khartoum, Khartoum, Sudan
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Chemical investigation of a strain of the marine-derived fungus Phoma sp. has led to the discovery of epoxyphomalin A (1) and B (2), two new prenylated polyketides with unusual structural features. Epoxyphomalin A (1) showed superior cytotoxicity at nanomolar concentrations toward 12 of a panel of 36 human tumor cell lines. In COMPARE analyses, the observed cytotoxic selectivity pattern of 1 did not correlate with those of reference anticancer agents with known mechanisms of action.
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