Journal
ORGANIC LETTERS
Volume 11, Issue 2, Pages 329-332Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol802506n
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With the aim of finding new natural product antimalarials, the novel indole alkaloids flinderole A-C were found to have selective antimalarial activities with IC50 values between 0.15-1.42 mu M. Flinderole A was isolated from the Australian plant Flindersia acuminata and flinderoles B and C from the Papua New Guinean plant F. amboinensis. Flinderoles A-C contain an unprecedented rearranged skeleton compared to their related isomers of the borreverine class of compounds.
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