4.8 Article

Novel Nucleophilic Heterocyclic Carbene Mediated Stereoselective Conjugate Addition of Enals to Nitrostyrenes via Homoenolate

Journal

ORGANIC LETTERS
Volume 11, Issue 24, Pages 5570-5573

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol901918x

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Funding

  1. Department of Science and Technology (DST), Govt. of India
  2. Raja Ramanna Fellowship
  3. Council of Scientific and Industrial Research (CSIR), New Delhi

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A stereoselective Michael addition of homoenolate, generated from enals by nucleophilic heterocyclic carbene (NHC) catalysis, to beta-nitrostyrenes is reported for the first time. The products of this reaction obtained in good yields are of potential value in the synthesis of a variety of acyclic and heterocyclic compounds.

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