Journal
ORGANIC LETTERS
Volume 11, Issue 24, Pages 5578-5581Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol9020942
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Funding
- National Natural Science Foundation of China [20672051]
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Generally used and highly reactive RMgBr reagents were effectively deactivated by bis[2-(N,N-dimethylamino)ethyl] ether and then were employed in the highly enantioselective addition of Grignard reagents to aldehydes. The reaction was catalyzed by the complex of commercially available (S)-BINOL and Ti(O'Pr-)(4) under mild conditions. Compared with the other observed Grignard reagents, alkyl Grignard reagents showed higher enantioselectivity and they achieved >99% ee.
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