Journal
ORGANIC LETTERS
Volume 11, Issue 18, Pages 4100-4103Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol9015767
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Funding
- Carlsberg Foundation
- French Ministry of Research
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The synthesis of a novel family of peptidomimetics composed of linear and cyclic alpha,beta-alternating peptoids is described. Oligomers consisting of up to six peptoid residues (n = 1-3) were synthesized on large scale with use of an efficient iterative solution-phase method and longer oligomers (n = 4, 5) were obtained by the coupling of appropriately protected shorter oligomers. Preliminary conformational studies of these hybrid peptoids are reported.
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