Journal
ORGANIC LETTERS
Volume 11, Issue 14, Pages 3072-3075Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol9011212
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- Ministry of Education, Culture, Sports, Science, and Technology, Japan
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The copper-mediated direct arylation of 1,3,4-oxadiazoles and 1,2,4-triazoles with aryl iodides proceeds efficiently in the presence of suitable ligands and bases. This method allows the installation of a variety of aryl moieties bearing a functional group such as ketone, ester, or nitrile so as to enable the facile construction of various functionalized oxadiazole and triazole core pi systems.
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