Journal
ORGANIC LETTERS
Volume 11, Issue 19, Pages 4438-4440Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol901803d
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The first synthesis of carbon-stapled beta(3)-peptides is reported. The precursor beta(3)-peptides, with -allyl beta-serines located in an i/i+3 relationship, were prepared on solid phase. We show that efficient ring-closing metathesis (RCM) of these new beta(3)-peptides proceeds smoothly either in solution or on an appropriate solid support. All products were generated with high selectivity for the E-isomer.
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