Journal
ORGANIC LETTERS
Volume 11, Issue 23, Pages 5422-5424Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol901997k
Keywords
-
Categories
Funding
- NIH [R37 CA44848, T32CA121938]
- UCSD Cancer Therapeutics Training Program
Ask authors/readers for more resources
Chemical examination of the secondary metabolites of a marine Saccharomonospora sp., isolated from marine sediments collected at the mouth of the La Jolla Submarine Canyon, yielded the unprecedented alkaloid lodopyridone (1). The low proton-to-carbon ratio of 1 precluded structure elucidation by NMR spectroscopic methods, thus the structure was defined by X-ray crystallography. Lodopyridone is cytotoxic to HCT-116 human colon cancer cells with IC50 = 3.6 mu M.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available