4.8 Article

Stereoselective Synthesis of Spirocyclic Oxindoles via Prins Cyclizations

Journal

ORGANIC LETTERS
Volume 11, Issue 15, Pages 3362-3365

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol901201k

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Funding

  1. NIGMS [P41 GM076263, P50 GM067041]

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The synthesis of spirocyclic oxindole pyran and oxepene frameworks using highly stereoselective Prins cyclizations of homoallylic and bis-homoallylic alcohols and isatin ketals is described.

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